Insig2 is associated with colon tumorigenesis and inhibits Bax-mediated apoptosis
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چکیده
منابع مشابه
Interaction of Caveolin-1 with Ku70 Inhibits Bax-Mediated Apoptosis
Caveolin-1, the structural protein component of caveolae, acts as a scaffolding protein that functionally regulates signaling molecules. We show that knockdown of caveolin-1 protein expression enhances chemotherapeutic drug-induced apoptosis and inhibits long-term survival of colon cancer cells. In vitro studies demonstrate that caveolin-1 is a novel Ku70-binding protein, as shown by the bindin...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2008
ISSN: 0020-7136
DOI: 10.1002/ijc.23510